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・ Serotonergic
・ Serotonergic cell groups
・ Serotonergic psychedelic
・ Serotonin
・ Serotonin (album)
・ Serotonin (disambiguation)
・ Serotonin acetyltransferase
・ Serotonin antagonist
・ Serotonin antagonist and reuptake inhibitor
・ Serotonin modulator and stimulator
・ Serotonin pathway
・ Serotonin receptor agonist
・ Serotonin releasing agent
・ Serotonin reuptake inhibitor
・ Serotonin syndrome
Serotonin transporter
・ Serotonin-dopamine releasing agent
・ Serotonin-dopamine reuptake inhibitor
・ Serotonin-norepinephrine releasing agent
・ Serotonin-norepinephrine-dopamine releasing agent
・ Serotonin–norepinephrine reuptake inhibitor
・ Serotonin–norepinephrine–dopamine reuptake inhibitor
・ Serotonylation
・ Serotta
・ Serotype
・ Serouj Kradjian
・ Serous carcinoma
・ Serous cystadenocarcinoma
・ Serous cystadenoma
・ Serous demilune


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Serotonin transporter : ウィキペディア英語版
Serotonin transporter

The serotonin transporter (SERT or 5-HTT) also known as the sodium-dependent serotonin transporter and solute carrier family 6 member 4 is a protein that in humans is encoded by the SLC6A4 gene. SERT is a type of monoamine transporter protein that transports serotonin from the synaptic cleft to the presynaptic neuron.
This transport of serotonin by the SERT protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is the target of many antidepressant medications, including those of the SSRI class. It is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, post-traumatic stress disorder and depression-susceptibility in people experiencing emotional trauma.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6532 )
==Function==
The serotonin transporter removes serotonin from the synaptic cleft back into the synaptic boutons. Thus, it terminates the effects of serotonin and simultaneously enables its reuse by the presynaptic neuron.〔
Neurons communicate by using chemical messengers like serotonin between cells. The transporter protein, by recycling serotonin, regulates its concentration in a gap, or synapse, and thus its effects on a receiving neuron’s receptors.
Medical studies have shown that changes in serotonin transporter metabolism appear to be associated with many different phenomena, including alcoholism, clinical depression, obsessive-compulsive disorder (OCD),
romantic love, hypertension and generalized social phobia.
The serotonin transporter is also present in platelets; there, serotonin functions as a vasoconstrictive substance.

Image:Serotonin (5-HT).svg|Serotonin


抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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